Presenters: Peter Kuhn, PhD and Jorge Nieva, MD. University of Southern California, Los Angeles, CA Abstract: The Current Status of Tumor BiomarkersThe past decade has seen tremendous advances in cancer care driven largely by better understanding of cancer genetics and biology. Characterization of the DNA changes driving cancer formation is now routine and it seems …

Continue reading “#aacr19: Physicist vs. physician: Digitizing clinical assessment and using it for evidence-based prediction of outcomes”

Presenter James B. Hicks, PhD. University of Southern California, Los Angeles, CA Description Cancer is a genetic disease that evolves over time and in response to treatment, whether in model systems or in the setting of human disease. It is therefore imperative to create tools to assess genomic and transcriptomic complexity in order to understand …

Continue reading “#aacr19: Deconvoluting Tumor Heterogeneity Using Single-Cell Genomics”

Presenters: Paymaneh D. Malihi1, Ryon P. Graf2, Carmen Ruiz Velasco1, Anand Kolatkar1, Angel E. Rodriguez2, Jerry Lee2, Ramsay Sutton2, Paul G. Corn3, Christopher J. Logothetis3, Ana M. Aparicio3, James Hicks1, Ryan Dittamore2, Amado J. Zurita3, Peter Kuhn1.  1University of Southern California, Los Angeles, CA; 2EPIC Sciences, San Diego, CA; 3MD Anderson Cancer Center, Houston, TX Abstract: A …

Continue reading “#AACR19: Genomic instability as a marker of poor prognosis in advanced prostate cancer: Subclonal insights from whole-genome sequencing of single circulating tumor cells”

USC scientists Dr. Stephanie Shishido will present results from a small cohort study from a clinical trial in which metastatic breast cancer patients with a rare form of the disease (ERBB2 mutated, HER2 non-amplified) were treated with the combination of Neratinib and Fulvestrant. This work focuses on the use of a blood sample for a …

Continue reading “#AACR19: Morphologic and genomic characterization of circulating tumor cells in patients with ERBB2 mutant HER2 non-amplified metastatic breast cancer treated with neratinib”

Presenters: Shoujie Chai1, Paymaneh D. Malihi1, Ana M. Apariciop2, Brian F. Chapin2, Matthew Lin1, Ryan Storgard1, Carmen Ruiz Velasco1, Anand Kolatkar1, James Hicks1, Peter Kuhn1. 1University of Southern California, Los Angeles, CA; 2The University of Texas MD Anderson Cancer Center, Houston, TX Abstract: Background: The absence of biomarkers that identify clinically meaningful biological subsets of prostate cancer …

Continue reading “#AACR19: Genomic characterization of circulating tumor cells in de novo metastatic prostate cancer”

Presenter: Liya Xu1, Jesse L. Berry2, Irsan Kooi3, A Linn Murphree2, Rishvanth K. Prabakar1, Mark W. Reid4, Kevin Stachelek4, Bao Han A. Le2, Lisa Welter1, Rima Jubran4, Thomas C. Lee2, Jonathan W. Kim2, Peter Kuhn1, David Cobrinik2, James B. Hicks1.  1University of Southern California, Los Angeles, CA; 2Children’s Hospital Los Angeles and the USC Roski Eye …

Continue reading “#AACR19: Genomic cfDNA analysis of aqueous humor in retinoblastoma (RB) predicts eye salvage”