#aacr19: Deconvoluting Tumor Heterogeneity Using Single-Cell Genomics


James B. Hicks, PhD.

University of Southern California, Los Angeles, CA


Cancer is a genetic disease that evolves over time and in response to treatment, whether in model systems or in the setting of human disease. It is therefore imperative to create tools to assess genomic and transcriptomic complexity in order to understand the biological. Single cell genomics and transcriptomics can provide the most detailed analysis of tumor complexity, however, the sensitivity of the methods is often limited by expense and access to cells. In this session, I’ll begin by providing examples of the ways that tumor heterogeneity that is being addressed by single cell genomics including recently developed high throughput multi-omics methods combining genomics with epigenomics and proteomics, along with the analytical tools necessary to deal with this complex data stream. The goal of the session is to have participants generate a discussion of how these tools can be applied to their specific problems and how they can be extended into new discoveries.

Join Professor Hicks at Meet-the-Expert Session on April 3, 2019, 7:00 AM – 8:00 AM at Georgia Ballrm 3- Bldg C- GWCC

james hicks, Phd

Research Professor
Department of Biological Sciences 
Dornsife College of letters, arts, and sciences