Publications

2018: 

Keating SM, Taylor DL, Plant AL. Litwack ED, Kuhn P, Greenspan EJ, Hartshorn CM, Sigman CC, Kelloff GJ, Chang DD, Friberg G, Lee JSH, Kuida K. Opportunities and Challenges in Implementation of Multiparameter Single Cell Analysis Platforms for Clinical Translation. Clin Transl Sci 2018;11:267-276

Zaki Hasnain, Ming Li, Tanya Dorff, David Quinn, Naoto T. Ueno, Sriram Yennu, Anand Kolatkar, Cyrus Shahabi, Luciano Nocera, Jorge Nieva, Peter Kuhn, Paul K. Newton. Low-dimensional dynamical characterization of human performance of cancer patients using motion data. Clinical Biomechanics. 2018 Jul;56:61-69. doi: 10.1016/j.clinbiomech.2018.05.007. Epub 2018 May 18. PubMed>>

Chalfin HJ, Glavaris SA, Malihi PD, Sperger JM, Gorin MA, Lu C, Goodwin CR, Chen Y, Caruso EA, Dumpit R, Kuhn P, Lang JM, Nelson PS, Luo J, Pienta KJ.  Prostate cancer disseminated tumor cells are rarely detected in the bone marrow of localized patients undergoing radical prostatectomy across multiple rare cell detection platforms. J Urol 2018;199:1494-1501

Malihi P, Morikado M, Welter L, Liu ST, Miller ET, Cadaneanu RM, Knudsen BS, Lewis MS, Carlsson A, Ruiz Velasco C, Kolatkar A, Rodriguez-Lee M, Garraway IP, Hicks J, Kuhn P. Clonal diversity revealed by morphoproteomic and copy number profiles of single prostate cancer cells at diagnosis. Converg Sci Phys Oncol 2018;4:015003

Gerdtsson E, Pore M, Thiele J-A, Sandstrom Gerdtsson A, Malihi PD, Nevarez R, Kolatkar A, Ruiz Velasco C, Wix S, Singh M, Carlsson A, Zurita AJ, Logothetis C, Merchant AA, Hicks J, Kuhn P. Multiplex protein detection on circulating tumor cells from liquid biopsies using imaging mass cytometry. Converg Sci Phys Oncol 2018;4:015002

In GK, Mason J, Lin S, Newton PK, Kuhn P, Nieva J. Development of metastatic brain disease involves progresson through lung metastases in EGFR mutated non-small cell lung cancer. Converg Sci Phys Oncol 2017;3:035002

Rodriguez-Lee M, Kolatkar A, McCormick M, Dago, AE, Kendall J, Carlsson NA, Bethel K, Greenspan E, Hwang S, Waitman K, Nieva J, Hicks J, Kuhn P. Effect of blood collection tube type and time to processing on the enumeration and high-content characterization of circulating tumor cells using the high-definition single cell assay. Arch Pathol Lab Med 2018;142:198-207

2017: 

Berry JL, Xu L, Murphree AL, Krishnan S, Stachelek K, Zolfaqhari E, Mc Govern K, Lee TC, garlsson A, Kuhn P, Kim JW, Cobrinik D, Hicks J. Potential of Aqueous Humor as a Surrogate Tumor Biopsy for Retinoblastoma. JAMA Ophthalmol 2017 135:1221-1230

Grossman RL, Abel B, Angiuoli S, Barrett JC, Bassett D, Bramlett K, Blumenthal GM, Carlsson A, Cortese R, DiGiovanna J, Davis-Dusenbery B, Dittamore R, Eberhard DA, Febbo P, Fitzsimons M, Flamig Z, Godsey J, Goswami J, Gruen A, Guzman FO, Han J, Hayes D, Hicks J, Holloway D, Hovelson D, Johnson J, Juhl H, Kalamegham R, Kamal R, Kang Q, Kelloff GJ, Klozenbuecher M, Kolatkar A, Kuhn P, Langone K, Leary R, Loverso P, Manmathan H, Martin AM, Martini J, Miller D, Mitchell M, Morgan T, Mulpuri R, Nguyen T, Otto G, Pathak A, Peters E, Philip R, Posadas E, Reese D, Reese MG, Robinson D, Rossi AD, Sakul H, Schageman J, Singh S, Scher HI, Schmitt K, Silvestro A, Simmons J, Simmons T, Sislow J, Talasaz A, Tang P, Tewari M, Tomlins S, Toukhy H, Tseng HR, Tuck M, Tzou A, Vinson J, Wang Y, Wells W, Welsh A, Wilbanks J, Wolf J, Young L, Lee JS, Leiman LC.  Collaborating to Compete: Blood Profiling Atlas in Cancer (BloodPAC) Consortium.  Clin Pharmacol Ther 2017;101:589-592

Dive C, Shishido SN, Kuhn P. Cancer Moonshot connecting International Liquid Biopsy efforts through academic partnership. Clin Pharmacol Ther 2017;101:622-624

Kuhn P, Keating SM, Baxter GT, Thomas K, Kolatkar A, Sigman CC. Lessons learned: Transfer of the high-definition circulating tumor cell assay platform to development as a commercialized clinical assay platform. Clin Pharmacol Ther 2017;102:777-785

Thiele J-A, Bethel K, Kralickova M, Kuhn P. Circulating Tumor Cells: Fluid Surrogates of Solid Tumors. Annu Rev Pathol 2017;12:419-447

Abreu A, Fay, C, Park D, Quinn D, Dorff T. Carpten  J, Kuhn P, Gill P, Almeida F, Gill I. Robotic salvage retroperitoneal and pelvic lymph node dissection for ’node-only’ recurrent prostate cancer: technique and initial series. BJU Int 2017; 120:401-408

2016:

Dizon K, Shishido S, Kuhn P. Circulating Tumor Cells: High Throughput Imaging of CTCs and Bioinformatic Analysis. Springer, Liquid Biopsies: Searching for Cancer in the Blood, 2016.

Williamson S, Metcalf R, Trapani F, Mohan S, Antonello J, Abbott B, Leong H-S, Chester C, Simms N, Polanski R, Nonaka D, Priest L, Fusi A, Carlsson F, Carlsson A, Hendrix M, Seftor R, Seftor, E, Rothwell D, Hughes A, Hicks J, Miller C, Kuhn P, Brady G, Simpson K, Blackhall F, Dive C. Vasculogenic mimicry in small cell lung cancer. Nat Commun 2016;7:13322.

Carlsson A, Kuhn P, Luttgen MS, Dizon KK, Troncoso P, Corn PG, Kolatkar A, Hicks, JB, Logothetis C, Zurita AJ. Paired high-content analysis of prostate cancer cells in bone marrow and Blood characterizes increased androgen receptor expression in tumor cell clusters. Clin Cancer Res 2017;23:1722-1732.

Gross M, Dorff T, Quinn D, Agus D, Luttgen M, Bethel K, Kolatkar A, Kuhn P. Rapid changes in circulating tumor cells following anti-angiogenic therapy. Converg Sci Phys Oncol 2015:015002.

Ko AH, Bekaii-Saab T, Van Ziffle J, Mirzoeva OM, Joseph NM, Talasaz A, Kuhn P, Tempero MA, Collisson EA, Kelley RK, Venook AP, Dito E, Ong A, Ziyeh S, Courtin R, Linetskaya R, Tahiri S, Korn WM. A Multicenter, Open-Label Phase II Clinical Trial of Combined MEK plus EGFR Inhibition for Chemotherapy-Refractory Advanced Pancreatic AdenocarcinomaClin Cancer Res. 2016 Jan 1;22(1):61-8. doi: 10.1158/1078-0432.CCR-15-0979. Epub 2015 Aug 6. PubMed>>

Mitrugno A, Tormoen GW, Kuhn P, McCarty OJ., The prothrombotic activity of cancer cells in circulation. Blood Rev. 2016 Jan;30(1):11-9. doi: 10.1016/j.blre.2015.07.001. Epub 2015 Jul 14. PubMed>>

2015:

Timour Baslan, Jude Kendall, Brian Ward, Hilary Cox, Anthony Leotta, Linda Rodgers, Michael Riggs, Sean D’Italia, Guoli Sun, Mao Yong, Kristy Miskimen, Hannah Gilmore, Michael Saborowski, Nevenka Dimitrova, Alexander Krasnitz, Lyndsay Harris, Michael Wigler and James Hicks. Optimizing sparse sequencing of single cells for highly multiplex copy number profiling. Genome Res. 2015 May;25(5):714-24. doi: 10.1101/gr.188060.114. Epub 2015 Apr 9.PubMed>>

Jorge Nieva, Kelly Bethel, Carole Baas and Peter Kuhn, Convergent Science Physical Oncology Converg. Sci. Phys. Oncol. 1 010201 doi:10.1088/2057-1739/1/1/010201 Link>>

Emerson T. et al., Fourier-ring descriptor to characterize rare circulating cells from images generated using immunofluorescence microscopy. Comput Med Imaging Graph. 2015 Mar; 40:70-87. doi: 10.1016/j.compmedimag.2014.10.003. PubMed>>

Ruiz C. et al., Limited genomic heterogeneity of circulating melanoma cells in advanced stage patients.Physical Biology 2015 Jan 9;12(1):016008. doi: 10.1088/1478-3975/12/1/016008. PubMed>>

2014:

Rodriguez-Lee M., Kuhn P. and Webb D. R. Advancing Cancer Patient Care by Integrating Circulating Tumor Cell Technology to Understand the Spatial and Temporal Dynamics of Cancer. Drug Development Res. 75 : 384–392 (2014) Epub 2014/09/04. DOI: 10.1002/ddr.21225. Link>>

Dago A.E. et al. Rapid phenotypic and genomic change in response to therapeutic pressure in prostate cancer inferred by high content analysis of single circulating tumor cells. PloS one. 2014;9(8):e101777. Epub 2014/08/02. doi: 10.1371/journal.pone.0101777. PubMed PMID: 25084170; PubMed Central PMCID: PMCPmc4118839. PubMed>>

Carlsson A., et al. Circulating Tumor Microemboli Diagnostics for Patients with Non–Small-Cell Lung Cancer. Journal of Thoracic Oncology. 2014;9(8):1111-9 10.097/JTO.0000000000000235. Link >>

Bazhenova L. et al. Adrenal metastases in lung cancer: clinical implications of a mathematical model. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2014;9(4):442-6. doi: 10.1097/JTO.0000000000000133. PubMed PMID: 24736064; PubMed Central PMCID: PMC398954.7 PubMed >>

Phillips KG, Kuhn P, McCarty OJ. Physical biology in cancer. 2. The physical biology of circulating tumor cells. American journal of physiology Cell physiology. 2014;306(2):C80-8. doi: 10.1152/ajpcell.00294.2013. PubMed PMID: 24133063; PubMed Central PMCID: PMC3919989. PubMed >>

Bethel K, et al. Fluid phase biopsy for detection and characterization of circulating endothelial cells in myocardial infarction. Physical biology. 2014;11(1):016002. doi: 10.1088/1478-3975/11/1/016002. PubMed PMID: 24406475. PubMed >

2013:

Nair VS, et al. An observational study of circulating tumor cells and (18)F-FDG PET uptake in patients with treatment-naive non-small cell lung cancer. PloS one. 2013;8(7):e67733. doi: 10.1371/journal.pone.0067733. PubMed PMID: 23861795; PubMed Central PMCID: PMC3702496. PubMed>>

PSOC Network, et al. A physical sciences network characterization of non-tumorigenic and metastatic cells. Scientific reports. 2013;3:1449. doi: 10.1038/srep01449. PubMed PMID: 23618955; PubMed Central PMCID: PMC3636513. PubMed>>

Newton PK, et al. Spreaders and sponges define metastasis in lung cancer: a Markov chain Monte Carlo mathematical model. Cancer research. 2013;73(9):2760-9. doi: 0.1158/0008-5472.CAN-12-4488. PubMed PMID: 23447576; PubMed Central PMCID: PMC3644026. PubMed>>

2012:

Cho E. H. Circulating tumor cells as emerging tumor biomarkers in lung cancer J Thorac Dis. Oct 2012; 4(5): 444–445. doi: 10.3978/j.issn.2072-1439.2012.08.13PMCID: PMC3461062. PubMed>>

Boshuizen R., Kuhn P., van den Heuvel M. Circulating tumor cells in non-small cell lung carcinoma J Thorac Dis. Oct 2012; 4(5): 456–458. doi: 10.3978/j.issn.2072-1439.2012.08.21 PMCID: PMC3461060. PubMed>>

Lee AM, et al. Modeling and Simulation of Procoagulant Circulating Tumor Cells in Flow Front Oncol. 2012; 2: 108. doi: 10.3389/fonc.2012.00108. PMCID: PMC3442195.  PubMed>>

Lee AM, et al. A low-dimensional deformation model for cancer cells in flow. Physics of fluids. 2012;24(8):81903. doi: 10.1063/1.4748811. PubMed PMID: 23024578; PubMed Central PMCID: PMC3443115. PubMed>>

Nieva J. & Kuhn P. Fluid biopsy for solid tumors: a patient’s companion for lifelong characterization of their disease Future Oncol. Aug 2012; 8(8): 989–998. doi: 10.2217/fon.12.91 PMCID: PMC3658625.  PubMed>>

Scott J., Kuhn P. and Anderson A. R. Unifying metastasis — integrating intravasation, circulation and end-organ colonization Nature Reviews Cancer 12, 445-446. doi:10.1038/nrc3287 PMCID: PMC3387999.  FullText >>

Phillips KG, et al. Optical quantification of cellular mass, volume, and density of circulating tumor cells identified in an ovarian cancer patient. Frontiers in oncology. 2012;2:72. doi: 10.3389/fonc.2012.00072. PubMed PMID: 22826822; PubMed Central PMCID: PMC3399133. PubMed>>

Phillips KG, et al. Quantification of cellular volume and sub-cellular density fluctuations: comparison of normal peripheral blood cells and circulating tumor cells identified in a breast cancer patient. Frontiers in oncology. 2012;2:96. doi: 10.3389/fonc.2012.00096. PubMed PMID: 22934287; PubMed Central PMCID: PMC3414893. PubMed>>

Newton PK, et al. A stochastic Markov chain model to describe lung cancer growth and metastasis. PloS one. 2012;7(4):e34637. doi: 10.1371/journal.pone.0034637. PubMed PMID: 22558094; PubMed Central PMCID: PMC3338733.  PubMed>>

Nieva J.,et al. High definition imaging of circulating tumor cells and associated cellular events in non-small cell lung cancer patients; a longitudinal analysis Phys Biol. Feb 2012; 9(1): 016004. doi: 10.1088/1478-3975/9/1/016004 PMCID: PMC3388002.  PubMed>>

Marrinucci D. et al. Fluid biopsy in patients with metastatic prostate, pancreatic and breast cancers. Phys Biol. Feb 2012; 9(1): 016003. doi: 10.1088/1478-3975/9/1/016003 PMCID: PMC3387996. PubMed>>

Wendel M., et al. Fluid biopsy for circulating tumor cell identification in patients with early-and late-stage non-small cell lung cancer: a glimpse into lung cancer biology. Phys Biol. Feb 2012; 9(1): 016005. doi: 10.1088/1478-3967/9/1/016005 PMCID: PMC3387995. PubMed>>

Kuhn P. & Bethel K. EDITORIAL:A fluid biopsy as investigating technology for the fluid phase of solid tumors Phys Biol. Feb 2012; 9(1): 010301. doi:10.1088/1478-3975/9/1/010301. iop link>>

Lazar D. C., et al. Cytometric comparisons between circulating tumor cells from prostate cancer patients and the prostate-tumor-derived LNCaP cell line. Phys Biol. Feb 2012; 9(1): 016002. doi: 10.1088/1478-3975/9/1/016002 PMCID: PMC3387997. PubMed>>

Cho E. H., et al. Characterization of circulating tumor cell aggregates identified in patients with epithelial tumors. Phys Biol. Feb 2012; 9(1): 016001. doi: 10.1088/1478-3975/9/1/016001 PMCID: PMC3387999. PubMed>>