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Longitudinal dataset containing detailed clinical and demographic information on 446 early stage breast cancer patients diagnosed between 1975 and 2009 at Memorial Sloan Kettering Cancer Center. Patients in the study were followed from their first doctor visit throughout their metastatic progression and treatment schedule. At diagnosis, none of the patients had any presentation of metastases. All patients eventually developed metastatic disease. As of August 2013, 273 of the patients were deceased.
Longitudinal dataset containing detailed clinical and demographic information on 3735 early stage breast cancer patients diagnosed at MD Anderson Cancer Center. Patients in the study were followed from their first doctor visit throughout their metastatic progression and treatment schedule. At diagnosis, none of the patients had any presentation of metastases. All patients eventually developed metastatic disease. As of July 2016, 2628 of the patients were deceased.
Select demographics to view a patient subgroup. Checking every checkbox in a particular row will yield the same result as not checking any checkbox. Click "Add Patient Group" below when finished making choices. If the subgroup selected contains too few patients, an alert will be generated and your results will not be displayed. Try again by broadening your search a little.
Histogram bars show time elapsed between two events for patient subset, binned yearly, and grouped by selected demographic. Pie chart slices illustrate percentage of patients represented while attached table lists total and percentage values for each demographic group. Hover mouse over a bar of the histogram to update pie chart and table with statistics for that time period. Hover mouse over a slice of the pie chart to highlight that specific demographic in the histogram. Use dropdown menus to select new time events and demographic option. Click "Add Histogram" to add additional set of diagrams below last set. Click "Remove Histogram" to remove designated set.
Rings from inner to outermost ring show progression patterns of primary breast cancer patients (pink ring) and formation of metastases (subsequent rings). Circular arc length of each sector represents the percentage of patients with a metastatic tumor in that location. Default diagram is a 10 year progression diagram depicting metastatic progression pathways 10 years after diagnosis. Only patients with known progression pathways for the year indicated are used for this diagram (i.e. - patients that left the study before the time are censored out). Check the "Include Censored Data" checkbox and "Update Diagram" button to include all patients. Use the second slider to view yearly timepoints starting from diagnosis. Use the first slider and the "Update Diagram" button to change the set of diagrams to a new progression interval.
Markov chain networks of metastatic breast cancer shown as circular chord diagrams. Chord widths at their respective starting locations represent one-step transition probabilities between two sites. Primary breast cancer is located on top with metastatic sites ordered clockwise in decreasing order according to transition probability from primary. Click the base of a node to isolate paths connected to that node. Hover mouse over base of a chord for transition probabilities.
Pathway diagrams showing two-step pathways emanating from breast (pink ring). Nodes are classified as a "spreader" (red) or "sponge" (blue) based on the ratio of the incoming and outgoing two-step probabilities. Bottom value shows percentage of total pathways that is represented. Hover mouse over a node to view incoming (green) and outgoing pathways (red). Use slider to update the number of two-step pathways that is shown.