Bladder Cancer Progression Models

Related Publications

Dataset(s)

Longitudinal dataset containing detailed clinical and demographic information on 3505 bladder cancer patients.

Demographic Options

Select demographics to view a patient subgroup. Checking every checkbox in a particular row will yield the same result as not checking any checkbox. Click "Add Patient Group" below when finished making choices. If the subgroup selected contains too few patients, an alert will be generated and your results will not be displayed. Try again by broadening your search a little.

Kaplan-Meier Survival Curve

Temporal Diagrams

Histogram bars show time elapsed between two events for patient subset, binned yearly, and grouped by selected demographic. Pie chart slices illustrate percentage of patients represented while attached table lists total and percentage values for each demographic group. Hover mouse over a bar of the histogram to update pie chart and table with statistics for that time period. Hover mouse over a slice of the pie chart to highlight that specific demographic in the histogram. Use dropdown menus to select new time events and demographic option. Click "Add Histogram" to add additional set of diagrams below last set. Click "Remove Histogram" to remove designated set.

Spatiotemporal Diagrams

Rings from inner to outermost ring show progression patterns of primary bladder cancer patients (brown ring) and formation of metastases (subsequent rings). Circular arc length of each sector represents the percentage of patients with a metastatic tumor in that location. Default diagram is a 40 year progression diagram depicting metastatic progression pathways 40 years after diagnosis. Use the slider to view yearly timepoints starting from diagnosis.

Markov Networks

Markov chain networks of metastatic bladder cancer shown as circular chord diagrams. Chord widths at their respective starting locations represent one-step transition probabilities between two sites. Primary bladder cancer is located on top with metastatic sites ordered clockwise in decreasing order according to transition probability from primary. Click the base of a node to isolate paths connected to that node. Hover mouse over base of a chord for transition probabilities.

Reduced Diagrams

Pathway diagrams showing two-step pathways emanating from bladder (brown ring). Nodes are classified as a "spreader" (red) or "sponge" (blue) based on the ratio of the incoming and outgoing two-step probabilities. Bottom value shows percentage of total pathways that is represented. Hover mouse over a node to view incoming (green) and outgoing pathways (red). Use slider to update the number of two-step pathways that is shown.

Spreader/Sponge Diagrams