The Analytical Tools to Objectively Measure Human Performance (ATOM-HP) program is a two year pilot project between the National Cancer Institute’s Center for Strategic Initiatives and the... Read More
Congratulations to our Mathematical Oncology crew! The work entitled “SPATIOTEMPORAL PROGRESSION OF METASTATIC BREAST CANCER: A MARKOV CHAIN MODEL HIGHLIGHTING THE ROLE OF EARLY METASTATIC SITES” published in npj Breast Cancer was highlighted in Scientific Computing magazine.
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Researchers developed a mathematical model to forecast metastatic breast cancer survival using techniques usually reserved for weather prediction and financial forecasting. They looked at 25 years of data regarding 446 patients at Memorial Sloan Kettering and focused on a subgroup who were diagnosed…
A new USC-led initiative unites national cancer and defense resources in pursuit of a common goal: a quantitative way to determine just how healthy a patient is.
The project, dubbed Analytical Tools to Objectively Measure Human Performance (ATOM-HP), will create a high-quality performance status tracking system for cancer patients during therapy and long-term follow-up.
This program is a joint effort of the National Cancer Institute’s Center for Strategic Initiatives and the Department of Defense’s Rapid Reaction Technology Office.
The work entitled “SPATIOTEMPORAL PROGRESSION OF METASTATIC BREAST CANCER: A MARKOV CHAIN MODEL HIGHLIGHTING THE ROLE OF EARLY METASTATIC SITES” by Paul K. Newton and colleagues is the featured article in the last edition of npj Breast Cancer.
In this study, the authors found that spatiotemporal patterns of metastatic spread in breast cancer are neither random nor unpredictable and developed a Markov based model of breast cancer progression that has predictive capability. They used data from 446 patients, collected over several decades, to create a probability model that can predict patient survival according to the first site of metastasis. They propose that sites can be classified as ‘spreaders’ or ‘sponges’ on the basis of whether the cancer is likely to spread further. The model could help physicians to provide better prognoses and facilitate research into the biology of metastasis. The authors suggest that future models might also incorporate how therapy type and tumor size influence metastasis and survival.
npj Breast Cancer is a multidisciplinary research journal, published in partnership between the Breast Cancer Research Foundation (BCRF) and Nature Publishing Group (NPG).